abstract：:An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...

journal_title：Neuropsychobiology

authors： Noldy NE,Neiman J,el-Nesr B,Carlen PL

更新日期：1990-01-01 00:00:00

abstract：:Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...

journal_title：Neuropsychobiology

authors： Rosadini G,Sannita WG,Nobili F,Cenacchi T

更新日期：1990-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and somatostatin and beta-endorphin levels were measured in 12 patients with panic disorder before and after 7 months of treatment with alprazolam or imipramine. The concentrations of CSF monoamine metabolites and...

journal_title：Neuropsychobiology

authors： Lepola U,Jolkkonen J,Rimón R,Riekkinen P

更新日期：1989-01-01 00:00:00

abstract：:Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...

journal_title：Neuropsychobiology

authors： Smith AP,Tyrrell DA,al-Nakib W,Barrow PG,Higgins PG,Leekam S,Trickett S

更新日期：1989-01-01 00:00:00

abstract：:In the past, some researchers found increased cortisol and prolactin responses to the administration of fenfluramine in major-depressed patients. It was believed that the fenfluramine test could prove to constitute another challenge probe to reflect the central serotonergic function. The present study was conducted in...

journal_title：Neuropsychobiology

authors： Maes M,Jacobs MP,Suy E,Minner B,Raus J

更新日期：1989-01-01 00:00:00

abstract：:Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made before and 2 and 6 h af...

journal_title：Neuropsychobiology

authors： Bourin M,Auget JL,Colombel MC,Larousse C

更新日期：1989-01-01 00:00:00

abstract：:Fengabine is a new GABAmimetic compound active in animal models predictive of antidepressant activity. The present overview reports the results of 6 double-blind trials versus tricyclics (TCAs) (3 in outpatients and 3 in inpatients). Overall, 398 adult patients (149 males and 249 females) were treated; 194 with fengab...

journal_title：Neuropsychobiology

authors： Magni G,Garreau M,Orofiamma B,Palminteri R

更新日期：1989-01-01 00:00:00

abstract：:Intermittent short-lived episodes of depression were examined in a group of 20 recurrent suicidal attempters without major depression, classified misleadingly as borderline personality disorders on DSM-IIIR, during careful prospective follow-up for between 4 and 6 months. The duration of depressions clustered tightly ...

journal_title：Neuropsychobiology

authors： Montgomery SA,Montgomery D,Baldwin D,Green M

更新日期：1989-01-01 00:00:00

abstract：:Somatosensory event-related potentials (SERP) were recorded in 30 chronic young schizophrenic patients and in 15 age-matched controls. Objective SERP parameters were latencies, amplitudes and the determination of areas of the cognitive components N1 and P3 by integration. Highly significantly reduced areas and prolong...

journal_title：Neuropsychobiology

authors： Böning J,Drechsler F,Neuhauser B

更新日期：1989-01-01 00:00:00

abstract：:Like the industry, the medical profession takes now an interest in quality assurance programs. In the field of psychiatry, the quality assessment of antidepressive drug prescriptions is an ideal target. A brief review of previous studies reveals a high prevalence of the use of psychotropes among the general population...

journal_title：Neuropsychobiology

authors： Wilmotte J

更新日期：1989-01-01 00:00:00

abstract：:Ten closed head-injured patients and 10 matched control subjects participated in a study that examined quantitated EEG data during cognitive task performance. The head-injured patients performed significantly worse than controls on all four tasks and had significantly higher EEG amplitudes and amplitude variances. A d...

journal_title：Neuropsychobiology

authors： Randolph C,Miller MH

更新日期：1988-01-01 00:00:00

abstract：:Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of gluta...

journal_title：Neuropsychobiology

authors： Maillis A,Karayanidis F,Koutsoukos E,Angelopoulos E,Stefanis C

更新日期：1988-01-01 00:00:00

abstract：:Neural-network pattern classifiers were used to study the effects of long half-life flurazepam (30 mg) and quazepam (15 mg), and short half-life triazolam (0.5 mg) on non-REM sleep. We measured the magnitude of effect, time course, and EEG spectral signature of the three benzodiazepines as a function of third-of-night...

journal_title：Neuropsychobiology

authors： Gevins AS,Stone RK,Ragsdale SD

更新日期：1988-01-01 00:00:00

abstract：:To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. The time interval (2.7 h) between sleep onset and rectal temperature minimum before chronotherapy was shorter than the time interval after c...

journal_title：Neuropsychobiology

authors： Ozaki N,Iwata T,Itoh A,Kogawa S,Ohta T,Okada T,Kasahara Y

更新日期：1988-01-01 00:00:00

abstract：:As low-dose amphetamine stimulation of locomotor activity in the rat depends upon a mesolimbic dopaminergic substrate, neuroleptic antagonism of this behavior has been suggested as a model for studying antipsychotic activity. Animals in the present study received 21 days of chronic treatment with 1.0 mg/kg amphetamine...

journal_title：Neuropsychobiology

authors： Lynch MR,Kuhn HG,Carey RJ

更新日期：1988-01-01 00:00:00

abstract：:The present paper is a review of the use of psychophysiology in diagnosis and treatment of simple phobias. The paper begins with a definition and characterization of phobic fears, together with a description of prevalence rates, age onset, and gender differences. Acquisition is then discussed within a Three-Systems mo...

journal_title：Neuropsychobiology

authors： Hugdahl K

更新日期：1988-01-01 00:00:00

abstract：:The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. T...

journal_title：Neuropsychobiology

authors： Taylor SC,Johnston AL,Wilks LJ,Nicholass JM,File SE,Little HJ

更新日期：1988-01-01 00:00:00

abstract：:The medical histories of a group of 511 patients hospitalized for schizophrenia were examined for the occurrence of perinatal distress. These patients were part of a 40-year follow-up study, so that their prognostic outcome was known at the time of this study. In this way, 200 cases of chronic schizophrenia were compa...

journal_title：Neuropsychobiology

authors： Wilcox JA,Nasrallah HA

更新日期：1987-01-01 00:00:00

abstract：:Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...

journal_title：Neuropsychobiology

authors： Guéchot J,Lépine JP,Cohen C,Fiet J,Lempérière T,Dreux C

更新日期：1987-01-01 00:00:00

abstract：:In two studies experimentally induced colds slowed the speed of response in a serial reaction task. Responding was also slower during the incubation period of the illness, which shows that performance on such a task may be used to predict subsequent illness. Volunteers who had no significant clinical illness, but who ...

journal_title：Neuropsychobiology

authors： Smith AP,Tyrrell DA,Al-Nakib W,Coyle KB,Donovan CB,Higgins PG,Willman JS

更新日期：1987-01-01 00:00:00

abstract：:A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (less than 60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. less than 5...

journal_title：Neuropsychobiology

authors： Pugnetti L,Scarone S,Brambilla F

更新日期：1987-01-01 00:00:00

abstract：:Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...

journal_title：Neuropsychobiology

authors： Russell RW

更新日期：1987-01-01 00:00:00

abstract：:The performance on spatial and nonspatial associative learning tasks was tested in a sample of male drug-free DSM III-diagnosed schizophrenic patients and in a closely matched normal control group. Schizophrenics showed a worse performance on both versions of the task, but especially on the nonspatial one. A significa...

journal_title：Neuropsychobiology

authors： Kemali D,Maj M,Galderisi S,Monteleone P,Mucci A

更新日期：1987-01-01 00:00:00

abstract：:We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. The group B Ca2+ channel blocking agent caroverine was tested against meprobamate in inpatient treatment of alcohol withdrawal. Patients of both groups were similar in age, weight, duration of drin...

journal_title：Neuropsychobiology

authors： Koppi S,Eberhardt G,Haller R,König P

更新日期：1987-01-01 00:00:00

abstract：:Two independent samples of psychiatric outpatients (n = 52 and 60) with blood type A or O completed the Brief Symptom Inventory, an abbreviated version of the SCL-90. In both samples patients with blood type A scored significantly higher than those with type O on the 'Obsessive-Compulsive' and 'Psychoticism' factors. ...

journal_title：Neuropsychobiology

authors： Boyer WF

更新日期：1986-01-01 00:00:00

abstract：:The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...

journal_title：Neuropsychobiology

authors： Wilcox JA,Nasrallah HA

更新日期：1986-01-01 00:00:00

abstract：:The effects of lithium treatment on serotonin (5-HT) receptors in rat frontal cortex and hippocampus were investigated. Long-term lithium treatment strongly blocked 5-hydroxytryptophan-induced head twitches, while acute lithium administration by itself induced head twitches in rats, and ketanserin blocked this acute l...

journal_title：Neuropsychobiology

authors： Hotta I,Yamawaki S,Segawa T

更新日期：1986-01-01 00:00:00

abstract：:Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...

journal_title：Neuropsychobiology

authors： Prasad A

更新日期：1986-01-01 00:00:00

abstract：:The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...

journal_title：Neuropsychobiology

authors： Asnis GM,Eisenberg J,Lemus CZ,Halbreich U

更新日期：1986-01-01 00:00:00

abstract：:Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...

journal_title：Neuropsychobiology

authors： Lôo H,Benkelfat C,Poirier MF,Vanelle JM,Olié JP,Dennis T,Scatton B

更新日期：1986-01-01 00:00:00

abstract：:Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...

journal_title：Neuropsychobiology

authors： Carey RJ,Schwarting R

更新日期：1986-01-01 00:00:00

abstract：:The relation between fasting, a.m. plasma prolactin and plasma/homovanillic acid (HVA) was studied in 9 healthy males on one occasion and in 9 healthy females on two occasions (in the follicular and luteal phase of the menstrual cycle). There was a significant inverse correlation between plasma HVA and plasma prolacti...

journal_title：Neuropsychobiology

authors： Roy-Byrne PP,Rubinow DR,Linnoila M

更新日期：1986-01-01 00:00:00

abstract：:Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...

journal_title：Neuropsychobiology

authors： Eison MS

更新日期：1986-01-01 00:00:00

abstract：:Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...

journal_title：Neuropsychobiology

authors： Brambilla F,Aguglia E,Massironi R,Maggioni M,Grillo W,Castiglioni R,Catalano M,Drago F

更新日期：1986-01-01 00:00:00

abstract：:The somnopolygraphs of 26 sober chronic alcoholics were compared with those of an age-matched control group, after approximately 25 days of sobriety. The sleep efficiency index and latency to sleep onset were significantly disturbed in alcoholic subjects. There was a decrease in the number of REM episodes. Slow-wave s...

journal_title：Neuropsychobiology

authors： Snyder S,Karacan I

更新日期：1985-01-01 00:00:00

abstract：:The acute effects of alcohol (0.7 g/kg) on visual signal detection performance and critical flicker fusion frequency (CFF) of normal volunteers were investigated using a signal detection theory analysis. When signal probability was low, alcohol affected the stimulus sensitivity and the reaction times of hits. Under a ...

journal_title：Neuropsychobiology

authors： Jansen AA,de Gier JJ,Slangen JL

更新日期：1985-01-01 00:00:00

abstract：:Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with...

journal_title：Neuropsychobiology

authors： Dimpfel W

更新日期：1985-01-01 00:00:00

abstract：:The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...

journal_title：Neuropsychobiology

authors： Dimpfel W,Decker H

更新日期：1985-01-01 00:00:00

abstract：:The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...

journal_title：Neuropsychobiology

authors： Møller SE,Reisby N,Elley J,Krautwald O,Ortmann J,Larsen OB

更新日期：1985-01-01 00:00:00

abstract：:Premenstrual tension was studied in 16 females, using both biochemical and psychological parameters during the pre- and postmenstrual phases. Uptake of serotonin (5-HT) and the levels of 5-HT in platelet-rich plasma and platelet-poor plasmas were determined. Degrees of distress experienced pre- and postmenstrually wer...

journal_title：Neuropsychobiology

authors： Taylor DL,Mathew RJ,Ho BT,Weinman ML

更新日期：1984-01-01 00:00:00